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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Cold agglutinin disease


Other Names for this Disease

  • Anemia, hemolytic, cold antibody
  • CAD
  • Cold antibody disease
  • Cold antibody hemolytic anemia
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Cause

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What causes cold agglutinin disease?

The exact underlying cause of cold agglutinin disease (CAD) is not fully understood. The underlying cause of the primary form is often unknown (idiopathic). Secondary CAD may be associated with infections (such as mycoplasma, Epstein-Barr virus, cytomegalovirus, mumps, varicella, rubella, adenovirus, HIV, influenza, hepatitis C, legionnare disease, syphilis, or listeriosi); other autoimmune diseases (such as systemic lupus erythematosus); or certain cancers (such as non-Hodgkin's lymphoma or chronic lymphocytic leukemia).[1][2][3]
Last updated: 5/15/2014

References
  1. Harper JL. Pediatric Cold agglutinin disease. eMedicine. August 2011; http://emedicine.medscape.com/article/954954-overview. Accessed 1/20/2012.
  2. Georgy S. Cold agglutinin disease. eMedicine. November 2010; http://emedicine.medscape.com/article/135327-overview. Accessed 1/20/2012.
  3. Cold antibody hemolytic anemia. National Organization for Rare Disorders (NORD). 2006; http://www.rarediseases.org/rare-disease-information/rare-diseases/byID/723/viewAbstract. Accessed 1/20/2012.


Other Names for this Disease
  • Anemia, hemolytic, cold antibody
  • CAD
  • Cold antibody disease
  • Cold antibody hemolytic anemia
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.