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Genetic and Rare Diseases Information Center (GARD)

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Chronic recurrent multifocal osteomyelitis

Other Names for this Disease
  • Chronic multifocal osteomyelitis
  • CMO
  • CRMO
  • Multifocal osteomyelitis, chronic
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How might chronic recurrent multifocal osteomyelitis be treated?

Due to the rare nature of the condition, there is limited data regarding the best treatment approach for people with chronic recurrent multifocal osteomyelitis (CRMO). When CRMO occurs along with  psoriasis or inflammatory bowel disease the goal is to treat both the CRMO as well as the skin and gastrointestinal symptoms. In this situation, treatment with a TNF inhibitor may be recommended. Initial treatment of isolated CRMO often involves NSAIDs. If NSAIDs are unable to control pain, additional treatment options include antirheumatic drugs (e.g., corticosteroids, methotrexate, sulfasalazine, colchicine, and azithromycin), TNF inhibitors, or bisphosphonates.[1]
Last updated: 5/15/2013

  1. Ferguson PJ, Sandu M. Current understanding of the pathogenesis and management of chronic recurrent multifocal osteomyelitis. Curr Rheumatol Rep. 2012 Apr;14(2):130-41; Accessed 5/15/2013.

Clinical Trials & Research for this Disease

  • Orphanet lists clinical trials, research studies, and patient registries enrolling people with this condition. Click on Orphanet to view the list.