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Genetic and Rare Diseases Information Center (GARD)

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Chronic recurrent multifocal osteomyelitis

Other Names for this Disease
  • Chronic multifocal osteomyelitis
  • CMO
  • CRMO
  • Multifocal osteomyelitis, chronic
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Your Question

My son was diagnosed 2 years ago. At first he was doing good on his pain medication, but now he needs medicine before he can even get up as he can't move. Is there anything else that can treat his pain?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

How might chronic recurrent multifocal osteomyelitis be treated?

Due to the rare nature of the condition, there is limited data regarding the best treatment approach for people with chronic recurrent multifocal osteomyelitis (CRMO). When CRMO occurs along with  psoriasis or inflammatory bowel disease the goal is to treat both the CRMO as well as the skin and gastrointestinal symptoms. In this situation, treatment with a TNF inhibitor may be recommended. Initial treatment of isolated CRMO often involves NSAIDs. If NSAIDs are unable to control pain, additional treatment options include antirheumatic drugs (e.g., corticosteroids, methotrexate, sulfasalazine, colchicine, and azithromycin), TNF inhibitors, or bisphosphonates.[1]
Last updated: 5/15/2013