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Genetic and Rare Diseases Information Center (GARD)

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Chronic granulomatous disease


Other Names for this Disease

  • Granulomatous disease, chronic
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Overview

Chronic granulomatous disease (CGD) is a rare, inherited, primary immune deficiency disorder that affects certain white blood cells. It is characterized by an inability to resist repeated infectious diseases and a tendency to develop chronic inflammation. Symptoms usually begin in infancy or childhood and include life-threatening recurrent fungal and bacterial infections affecting the skin, lungs, and bones; swollen areas of inflamed tissues known as granulomas; and other symptoms. It is caused by mutations in any one of four different genes and is usually inherited in an autosomal recessive or X-linked recessive manner. Treatment consists of continuous antibiotic therapy to help prevent infections and corticosteroid drugs for treating granulomatous complications.[1]
Last updated: 5/12/2011

References

  1. Granulomatous Disease, Chronic. NORD. January 14, 2009; http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Granulomatous%20Disease%2C%20Chronic. Accessed 5/12/2011.
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Basic Information

In Depth Information

Other Names for this Disease
  • Granulomatous disease, chronic
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.