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Diseases

Genetic and Rare Diseases Information Center (GARD)

Other Names for this Disease
  • CRBM
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Symptoms


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What are the signs and symptoms of cherubism?

Cherubism is characterized by abnormal bone tissue in the lower part of the face. Beginning in early childhood, both the lower jaw (the mandible) and the upper jaw (the maxilla) become enlarged as bone is replaced with painless, cyst-like growths. These growths give the cheeks a swollen, rounded appearance and often interfere with normal tooth development. In some people the condition is very mild and barely noticeable, while in other cases are severe enough to cause problems with vision, breathing, speech, and swallowing. Enlargement of the jaw usually continues throughout childhood and stabilizes during puberty. The abnormal growths are gradually replaced with normal bone in early adulthood. As a result, many affected adults have a normal facial appearance.[1]
Last updated: 1/11/2011

References
  1. Cherubism. Genetics Home Reference. April 2007; http://ghr.nlm.nih.gov/condition=cherubism. Accessed 4/5/2010.