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Castleman's disease is thought to be sporadic. This means that it is thought to occur by chance in individuals who have no history of the condition in the family, and is not likely to recur in a family. We were unable to find reports of any familial cases of Castleman's disease in the available medical literature. It has been proposed that in affected individuals who are not infected with human herpes virus 8 (HHV-8), excess production of interleukin 6 (IL-6) may be caused by a mutation in a gene known as the interleukin 6 promoter. However, more research is needed to clarify this information.
Last updated: 10/1/2013
- Françoise SARROT-REYNAULD. Castleman disease. Orphanet. November 2006; http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=160. Accessed 10/1/2013.
- Castleman's Disease. NORD. December 8, 2010; http://www.rarediseases.org/rare-disease-information/rare-diseases/byID/532/viewAbstract. Accessed 10/1/2013.