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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Castleman's disease


Other Names for this Disease

  • Angiofollicular ganglionic hyperplasia
  • Angiofollicular lymph hyperplasia
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Inheritance

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Is Castleman's disease inherited?

Castleman's disease is thought to be sporadic. This means that it is thought to occur by chance in individuals who have no history of the condition in the family, and is not likely to recur in a family.[1] We were unable to find reports of any familial cases of Castleman's disease in the available medical literature. It has been proposed that in affected individuals who are not infected with human herpes virus 8 (HHV-8), excess production of interleukin 6 (IL-6) may be caused by a mutation in a gene known as the interleukin 6 promoter.[2] However, more research is needed to clarify this information.
Last updated: 10/1/2013

References
  1. Fran├žoise SARROT-REYNAULD. Castleman disease. Orphanet. November 2006; http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=160. Accessed 10/1/2013.
  2. Castleman's Disease. NORD. December 8, 2010; http://www.rarediseases.org/rare-disease-information/rare-diseases/byID/532/viewAbstract. Accessed 10/1/2013.


Other Names for this Disease
  • Angiofollicular ganglionic hyperplasia
  • Angiofollicular lymph hyperplasia
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.