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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Burkitt lymphoma


Other Names for this Disease
  • BL
  • Burkitt's lymphoma
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Inheritance


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Is Burkitt lymphoma inherited?

Burkitt lymphoma (BL) is typically not inherited; it is thought to be sporadic.[1] It generally occurs in individuals with no history of the condition in the family.

There is evidence that BL can be caused by changes (mutations) in the MYC gene in addition to exchanges of genetic material (translocations) involving the MYC gene and immunoglobulin genes (genes that provide instructions for antibodies).[2] However, these genetic changes are not inherited; they occur in the affected cells of affected individuals and are acquired during the lifetime. They are not passed on to offspring.

There was a report in 1986 which described 2 sisters in an American family who died of BL at ages 11 and 22 years. Their mother and 2 healthy brothers were known to have lymphocyte abnormalities. It was suggested that in this case, an inherited abnormality of lymphocytes was the cause for familial aggregation of BL.[2]
Last updated: 6/27/2012

References
  1. Catherine Patte. Burkitt lymphoma. Orphanet. February 2010; http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Expert=543&lng=EN. Accessed 6/26/2012.
  2. Marla J. F. O'Neill. Burkitt lymphoma; BL. OMIM. December 11, 2007; http://omim.org/entry/113970. Accessed 6/26/2012.