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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Adiposis dolorosa


Other Names for this Disease

  • Dercum disease
  • Dercum's disease
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Symptoms

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What are the signs and symptoms of adiposis dolorosa?

Adiposis dolorosa is primarily characterized by the development of muliple, painful lipomas (benign, fatty tumors). It is often associated with obesity; physical weakness and lack of energy (asthenia); and various other symptoms including depression, confusion, dementia and/or epilepsy (seizures).[1]

The lipomas occur anywhere in the body except the face and neck. The most common sites are the knees, upper thighs, back and upper arms. They may cause joint pain (arthralgia) when they are near the joints.[1] 
Pain associated with the lipomas can be debilitating; it usually worsens with movement or an increase in body weight.[2] Sparse pubic hair and underarm hair have been reported in some individuals.[1] The condition can also be associated with early congestive heart failure, severe hypothyroidism, joint pain, flushing episodes, tremors, cyanosis, high blood pressure, headaches, and nosebleeds.[2]

Last updated: 11/11/2013

The Human Phenotype Ontology provides the following list of signs and symptoms for Adiposis dolorosa. If the information is available, the table below includes how often the symptom is seen in people with this condition. You can use the MedlinePlus Medical Dictionary to look up the definitions for these medical terms.

Signs and Symptoms Approximate number of patients (when available)
Arthralgia 90%
Obesity 90%
Abnormal hair quantity 50%
Arthritis 7.5%
Autoimmunity 7.5%
Bruising susceptibility 7.5%
Constipation 7.5%
Developmental regression 7.5%
Diarrhea 7.5%
Dry skin 7.5%
Hypothyroidism 7.5%
Keratoconjunctivitis sicca 7.5%
Memory impairment 7.5%
Migraine 7.5%
Paresthesia 7.5%
Seizures 7.5%
Skin ulcer 7.5%
Sleep disturbance 7.5%
Teleangiectasia of the skin 7.5%
Xerostomia 7.5%
Autosomal dominant inheritance -
Middle age onset -
Painful subcutaneous lipomas -

Last updated: 9/2/2014

The Human Phenotype Ontology (HPO) has collected information on how often a sign or symptom occurs in a condition. Much of this information comes from Orphanet, a European rare disease database. The frequency of a sign or symptom is usually listed as a rough estimate of the percentage of patients who have that feature.

The frequency may also be listed as a fraction. The first number of the fraction is how many people had the symptom, and the second number is the total number of people who were examined in one study. For example, a frequency of 25/25 means that in a study of 25 people all patients were found to have that symptom. Because these frequencies are based on a specific study, the fractions may be different if another group of patients are examined.

Sometimes, no information on frequency is available. In these cases, the sign or symptom may be rare or common.


References
  1. Louis Dubertret. Adiposis dolorosa. Orphanet. May, 2008; http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=36397. Accessed 11/11/2013.
  2. Learning about Dercum Disease. National Human Genome Research Institute. July 2010; http://www.genome.gov/17516629. Accessed 5/13/2011.


Other Names for this Disease
  • Dercum disease
  • Dercum's disease
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.