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Genetic and Rare Diseases Information Center (GARD)

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Adie syndrome

Other Names for this Disease
  • Adie's Pupil
  • HAS
  • Holmes-Adie syndrome
  • Tonic, sluggishly reacting pupil and hypoactive or absent tendon reflexes
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What causes Adie syndrome?

Adie syndrome is thought to be the result of a viral or bacterial infection that causes inflammation and damage to neurons in the ciliary ganglion, an area of the brain that controls eye movements, and the spinal ganglion, an area of the brain involved in the response of the autonomic nervous system.  In rare cases, Adie syndrome may be inherited.[1] In these cases, it appears to follow an autosomal dominant pattern of inheritance.[2] 
Last updated: 5/3/2010

  1. NINDS Holmes-Adie syndrome Information Page. National Institute of Neurological Disorders and Stroke (NINDS). February 13, 2007; Accessed 5/3/2010.
  2. Adie Pupil. Online Mendelian Inheritance in Man (OMIM). July 5, 2006; Accessed 5/3/2010.