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Genetic and Rare Diseases Information Center (GARD)

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Axenfeld-Rieger syndrome

Other Names for this Disease
  • Goniodysgenesis hypodontia
  • Iridogoniodysgenesis with somatic anomalies
  • Rieger syndrome
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How is Axenfeld-Rieger syndrome inherited?

Axenfeld-Rieger syndrome is inherited in an autosomal dominant manner. All individuals inherit two copies of each gene. In autosomal dominant conditions, an individual only has to have one mutation in the gene to develop the condition. The mutation can be inherited from a parent, or can happen by chance for the first time in an individual.

Each child of an individual with Axenfeld-Rieger syndrome has a 50% chance of inheriting the mutation and the disorder. Offspring who inherit the mutation will have Axenfeld-Rieger syndrome, although they could be more or less severely affected than their parent.
Last updated: 4/11/2011