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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Worster Drought syndrome


Other Names for this Disease
  • Congenital suprabulbar paresis
  • Suprabulbar paresis congenital
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Your Question

Our son has Worster-Drought syndrome.  What is the liklihood of our daughter passing on the syndrome to any of her future children?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

If an individual has Worster-Drought syndrome, what is the chance that a relative could also be affected?

In most instances, only one individual in a family is affected by Worster-Drought syndrome (WDS).  Approximately 15% of individuals with WDS may develop this condition due to a genetic cause; this percentage is based on descriptions of a few families with multiple affected relatives.[1][2]  The particular gene or genes associated with WDS have not been identified and the pattern of inheritance in not known,[2] which makes it difficult to determine the exact chance that a relative of an individual with WDS could also be affected.
Last updated: 5/2/2013

References
  • Clark M, Harris R, Jolleff N, Price K, Neville BG. Worster-Drought syndrome: poorly recognized despite severe and persistent difficulties with feeding and speech. Developmental medicine and child neurology. 2010; 52:27-32. http://www.ncbi.nlm.nih.gov/pubmed/19824895. Accessed 5/1/2013.
  • Clark M, Neville BG. Familial and genetic associations in Worster-Drought syndrome and perisylvian disorders. American journal of medical genetics Part A. 2008; 146A:35-42. http://www.ncbi.nlm.nih.gov/pubmed/17994559. Accessed 5/1/2013.