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Genetic and Rare Diseases Information Center (GARD)

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Prader-Willi syndrome


Other Names for this Disease

  • Obesity, muscular hypotonia, mental retardation, short stature, hypogonadotropic hypogonadism, and small hands and feet
  • Prader Labhart Willi syndrome
  • PWS
  • Willi-Prader syndrome
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Overview

Prader-Willi syndrome (PWS) is a genetic condition that affects many parts of the body. Infants with PWS have low muscle tone, weak cry, feeding difficulties, and slow growth. Between 2 to 4 years of age, children with PWS become very focused on food and have difficulty controlling their appetite. The overeating often results in rapid weight gain and obesity. Individuals with PWS also often have developmental delays and short stature. Common behaviors include stubbornness, temper outburts, and obsessive-compulsive behavior. PWS is caused by missing or non-working genes on chromosome 15. Most cases are not inherited.[1][2]
Last updated: 4/30/2014

References

  1. Prader-Willi syndrome. Genetics Home Reference (GHR). July 2011; http://ghr.nlm.nih.gov/condition=praderwillisyndrome. Accessed 4/30/2014.
  2. Driscoll DJ, Miller JL, Schwartz S, and Cassidy SB. Prader-Willi Syndrome. GeneReviews. January 23, 2014; http://www.ncbi.nlm.nih.gov/books/NBK1330/. Accessed 4/30/2014.
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Basic Information

In Depth Information

  • The Online Mendelian Inheritance in Man (OMIM) is an catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Prader-Willi syndrome. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Obesity, muscular hypotonia, mental retardation, short stature, hypogonadotropic hypogonadism, and small hands and feet
  • Prader Labhart Willi syndrome
  • PWS
  • Willi-Prader syndrome
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.