Your browser does not support javascript:   Search for gard hereSearch for news-and-events here.

Diseases

Genetic and Rare Diseases Information Center (GARD)

Print friendly version

Prader-Willi syndrome


Other Names for this Disease
  • Obesity, muscular hypotonia, mental retardation, short stature, hypogonadotropic hypogonadism, and small hands and feet
  • Prader Labhart Willi syndrome
  • PWS
  • Willi-Prader syndrome
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Treatment


Newline Maker

How might Prader-Willi syndrome be treated?

Prader-Willi syndrome cannot be cured. However, early intervention can help people build skills for adapting to the disorder.  Early diagnosis can also help parents learn about the condition and prepare for future challenges.[1]

Exercise and physical activity can help control weight and help with motor skills. Speech therapy may be needed to help with oral skills.[1]

Human growth hormone has been found to be helpful in treating Prader-Willi syndrome.  It can help to increase height, decrease body fat, and increase muscle mass.  However, no medications have yet been found to control appetite in those with Prader-Willi.[1]
Last updated: 4/1/2011

References
  1. Prader-Willi Syndrome. National Institute of Child Health and Human Development (NICHD). March 24, 2010; http://www.nichd.nih.gov/health/topics/Prader_Willi_Syndrome.cfm. Accessed 3/24/2011.


Management Guidelines

  • GeneReviews provides current, expert-authored, peer-reviewed, full-text articles describing the application of genetic testing to the diagnosis, management, and genetic counseling of patients with specific inherited conditions. Click on the link to view the article on this topic.

Clinical Trials & Research for this Disease

  • ClinicalTrials.gov lists trials that are studying or have studied Prader-Willi syndrome. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies.

Medical Products

The medication(s) listed in the table(s) below have been approved by the Food and Drug Administration (FDA) for treatment of this condition. The FDA Office of Orphan Products Development designates "orphan products" for those that treat rare diseases affecting fewer than 200,000 Americans. The table(s) below may not be an exhaustive list of drugs or products used to treat this condition. There may be other products available that are not considered orphan products. To search for all FDA approved drugs, visit Drugs@FDA. You can find orphan products used to treat other conditions by searching the Orphan Drug Product Designation database.


Generic Name Somatropin [rDNA]
Trade Name
(Manufacturer Name)
Genotropin®
(Pfizer)
Indication
The FDA has approved this product to be used in this manner.
Long-term treatment of pediatric patients who have growth failure due to Prader-Willi syndrome (PWS).
More Information about this product Drug Information Portal

Generic Name Recombinant human luteinizing hormone
Trade Name
(Manufacturer Name)
Luveris® (injection)
(EMD Serono, Inc.)
Indication
The FDA has approved this product to be used in this manner.
Luveris (lutropin alfa for injection), concomitantly administered with Gonal-f (follitropin alfa for injection), is indicated for stimulation of follicular development in infertile hypogonadotropic hypogonadal women with profound LH deficiency (LH (less than) 1.2 IU/L).
More Information about this product Drug Information Portal