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Genetic and Rare Diseases Information Center (GARD)

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Watson syndrome

Other Names for this Disease
  • Cafe-au-lait spots with pulmonic stenosis
  • Pulmonic stenosis with cafe-au-lait spots
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Your Question

The doctors told me that my child has Watson syndrome. Will my next child be prone to this genetic disorder? What are the chances?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

How is Watson syndrome inherited?

Watson syndrome is inherited in an autosomal dominant pattern. People diagnosed with this condition typically have an affected parent. Each child of an individual with Watson syndrome has a 50% chance of inheriting the mutation.[1]
Last updated: 4/1/2013

What is Watson syndrome?

Watson syndrome is believed to be a variant of neurofibromatosis type 1. The symptoms of this condition are pulmonary valvular stenosis, cafe-au-lait spots and short stature. IQ test scores for individuals with Watson syndrome can range between 60-100.[2] Many people with this condition also have a larger than average head size (macrocephaly) and Lisch nodules. While mutations in the NF1 gene have been found in families with Watson syndrome, the exact cause of this condition is unknown. The condition is inherited in an autosomal dominant pattern. Treatment aims at managing the specific symptoms of an individual.[1]
Last updated: 4/2/2013