Print friendly version
Fetal valproate syndrome
Other Names for this Disease
- Embryofoetal valproic acid syndrome
- Valproic acid embryopathy
- Valproic acid fetal effects from
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.
 These features may become less prominent with time. Fetal valproate syndrome may also be associated with a wide range of other birth defects, as well as intellectual disability. In most cases the risks for a particular symptom or defect is not currently known.Fetal valproate syndrome occurs when a baby develops signs and symptoms as a result of an exposure to valproic acid during fetal development. Fetal exposure to valproic acid is associated with 2 to 3 times the general population risk for birth defects. This results in roughly a 6 to 9% risk of having a child with a birth defect versus the general population risk of 2 to 3%. Some children with this syndrome share common subtle facial characteristics, including thin arched eyebrows that may be spaced far apart, a wide nasal bridge, short nose with anteverted nostrils, thin upper lip, and smooth long philtrum (space between nose and lip).
Last updated: 3/5/2010
- Kini U et al. Dysmorphic features: an important clue to the diagnosis and severity of fetal anticonvulsant syndromes. Arch Dis Child Fetal Neonatal Ed. 2006;
- Kini U. Fetal valproate syndrome: a review. Paediatric and Perinatal Drug Therapy. 2006;
- Clayton-Smith J, Donnai D. Fetal valproate syndrome. J Med Genet. 1995;
- Kozma. Valproic acid embryopathy: Report of two siblings with further expansion of the phenotypic abnormalities and a review of the literature. American Journal of Medical Genetics. 2001;
- Nicolai J, Vles JSH, Aldenkamp AP. Neurodevelopmental delay in children exposed to antiepileptic drugs in utero: A critical review directed at structural study-bias. Journal of the Neurological Sciences. 2008;
On this page
- The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.
- MedlinePlus.gov provides more information on valproic acid. MedlinePlus is a Web site designed by the National Library of Medicine to help you research your health questions.
- TheFetus.net has an information page on fetal valporate syndrome. Click on TheFetus.net to view the page.
- The American Congress of Obstetricians and Gynecologists offers information on seizures disorders and pregnancy. Click on the link above to learn more.
In Depth Information
- Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
- The Online Mendelian Inheritance in Man (OMIM) database contains genetics resources that discuss Fetal valproate syndrome. Click on the link to go to OMIM and review these resources.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Fetal valproate syndrome. Click on the link to view a sample search on this topic.
Selected Full-Text Journal Articles
- Kini U. Fetal valproate syndrome: A review. Paediatric and Perinatal Drug Therapy. 2006;7(3):123-130.
- Kini U, Adab N, Vinten J, Fryer A, Clayton-Smith J. Dysmorphic features: an important clue to the diagnosis and severity of fetal anticonvulsant syndromes. Arch Dis Child Fetal Neonatal Ed. 2006 Mar;91(2):F90-5.