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Genetic and Rare Diseases Information Center (GARD)

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Hereditary neuropathy with liability to pressure palsy


Other Names for this Disease

  • HNPP
  • Polyneuropathy, familial recurrent
  • Tomaculous neuropathy
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Overview

Hereditary neuropathy with liability to pressure palsy (HNPP) is a disorder that affects peripheral nerves. This condition causes recurrent episodes of numbness, tingling, and/or loss of muscle function (palsy). An episode can last from several minutes to several months, but recovery is usually complete. Repeated incidents, however, can cause permanent muscle weakness or loss of sensation. The most common problem sites involve nerves in wrists, elbows, and knees. Symptoms usually begin during adolescence or early adulthood but may develop anytime from childhood to late adulthood. Symptoms vary in severity; many people never realize they have the disorder, while some people experience prolonged disability. This condition is caused by the loss of one copy of the PMP22 gene or alterations within the gene.[1]

Last updated: 7/23/2009

References

  1. Hereditary neuropathy with liability to pressure palsies. Genetics Home Reference. April 2007; http://ghr.nlm.nih.gov/condition=hereditaryneuropathywithliabilitytopressurepalsies. Accessed 7/20/2009.
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  • Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
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Other Names for this Disease
  • HNPP
  • Polyneuropathy, familial recurrent
  • Tomaculous neuropathy
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.