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Genetic and Rare Diseases Information Center (GARD)

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Central post-stroke pain

Other Names for this Disease
  • Central pain syndrome
  • Dejerine Roussy syndrome
  • Posterior thalamic syndrome
  • Retrolenticular syndrome
  • Thalamic hyperesthetic anesthesia
More Names
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How might central post-stroke pain be treated?

Treatment of central post-stroke pain (CPSP) is known to be challenging.[1] Pain medications (analgesics) often provide some reduction of pain, but not complete relief of pain. Tricyclic antidepressants such as nortriptyline, or anticonvulsants such as gabapentin can be useful. Lowering stress levels appears to reduce pain.[2] Other treatment alternatives have included the administration of a sympathetic blockade (a type of nerve block) and a guanethidine block, as well as psychological evaluation and treatment. Rarely, surgery is necessary.[3] Stereotactic radiosurgery of the pituitary has been used to treat CPSP with some success.[1] Other forms of potential treatments for CPSP that have been discussed in the literature include transcutaneous electrical nerve stimulation (TENS); deep brain stimulation; and motor cortex stimulation.[4]

Last updated: 1/24/2011

  1. YiLi Zhou. CHAPTER 48 – Principles of Pain Management. Bradley: Neurology in Clinical Practice, 5th ed.[Electronic version]. Deutschland: Butterworth-Heinemann; 2008 ; 905.
  2. NINDS Central Pain Syndrome Information Page. National Institute of Neurological Disorders and Stroke (NINDS). January 13, 2011; Accessed 1/23/2011.
  3. Robert Gould, Susan S Barnes. Shoulder and Hemiplegia. eMedicine. February 5, 2009; Accessed 1/23/2011.
  4. G D Schott. From thalamic syndrome to central poststroke pain. Journalof Neurology, Neurosurgery, and Psychiatry. December, 1996; 61(6):560-564. Accessed 1/23/2011.

Clinical Trials & Research for this Disease

  • lists trials that are studying or have studied Central post-stroke pain. Click on the link to go to to read descriptions of these studies.
  • The Research Portfolio Online Reporting Tool (RePORT) provides access to reports, data, and analyses of research activities at the National Institutes of Health (NIH), including information on NIH expenditures and the results of NIH-supported research. Although these projects may not conduct studies on humans, you may want to contact the investigators to learn more. To search for studies, click on the link and enter the disease name in the "Terms Search" box. Then click "Submit Query".