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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Stiff person syndrome


Other Names for this Disease

  • Morsch Woltman syndrome
  • SPS
  • Stiff man syndrome
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Treatment

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How might stiff person syndrome be treated?

Treatment of stiff person syndrome (SPS) focuses on the specific symptoms present in each person. Benzodiazepines may be used to treat muscle stiffness and episodic spasms; baclofen may be used in addition to benzodiazepines. Anti-seizure drugs have reportedly been effective for some people. More recently, studies have shown that intravenous immunoglobulin (IVIG) is effective in improving many of the symptoms of SPS.[1] Research involving additional treatment options for SPS is ongoing.

Additional information about the treatment of stiff person syndrome can be viewed on Medscape Reference's Web site.
Last updated: 10/8/2014

References
  1. Stiff person syndrome. NORD. July 13, 2010; http://www.rarediseases.org/rare-disease-information/rare-diseases/byID/326/viewAbstract. Accessed 10/8/2014.


Management Guidelines

  • Project OrphanAnesthesia is a project whose aim is to create peer-reviewed, readily accessible guidelines for patients with rare diseases and for the anesthesiologists caring for them. The project is a collaborative effort of the German Society of Anesthesiology and Intensive Care, Orphanet, the European Society of Pediatric Anesthesia, anesthetists and rare disease experts with the aim to contribute to patient safety.

Clinical Trials & Research for this Disease

  • The Centers for Mendelian Genomics program is working to discover the causes of rare genetic disorders. For more information about applying to the research study, please visit their website.
  • ClinicalTrials.gov lists trials that are studying or have studied Stiff person syndrome. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies.
Other Names for this Disease
  • Morsch Woltman syndrome
  • SPS
  • Stiff man syndrome
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.