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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Steatocystoma multiplex


Other Names for this Disease
  • Multiple sebaceous cysts
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Cause


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What causes steatocystoma multiplex?

Mutations in a gene called keratin 17 (KRT17) have been identified in some individuals with inherited steatocystoma multiplex. In these families the condition is inherited in an autosomal dominant fashion.[1][2][3]

In other cases the condition occurs sporadically. This may mean that it is due to a gene mutation that was not inherited, but occurred for the first time in the affected individual. A sporadic condition may also be non-genetic and occur by chance, in which case it is not likely to recur in a family.  In many sporadic cases of steatocystoma multiplex, mutations in the KRT17 gene have not been identified.[1]

Cases of steatocystoma multiplex have also been reported in association with pachyonychia congenita, acrokeratosis verruciformis, hypertrophic lichen planus, hypohidrosis, hidradenitis suppurativa, and natal teeth.[4]

Last updated: 6/8/2012

References
  1. Chu DH. Steatocystoma multiplex. Dermatol Online J. 2003 Oct;
  2. Pamoukian VN, Westreich M. Five generations with steatocystoma multiplex congenita: a treatment regimen. Plast Reconst Surg. 1997;
  3. Steatocystoma multiplex. Online Mendialian Inheritance in Man. 1997; http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=184500. Accessed 11/10/2009.
  4. Naik NS. Steatocystoma multiplex. Dermatol Online J. 2000 Sep;