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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Russell-Silver syndrome


Other Names for this Disease
  • Silver-Russell dwarfism
  • Silver-Russell syndrome
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Inheritance


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Is Russell-Silver syndrome inherited?

Most cases of Russell-Silver syndrome are sporadic, which means they occur in people with no history of the condition in their family. Less commonly, Russell-Silver syndrome can run in families. In some affected families, the condition appears to have an autosomal dominant pattern of inheritance. Autosomal dominant inheritance means one copy of a genetic change in each cell is sufficient to cause the disorder. In other families, the condition has an autosomal recessive pattern of inheritance. Autosomal recessive inheritance means both copies of a gene are altered in each cell. The parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but they typically do not show signs and symptoms of the condition.[1]
Last updated: 2/11/2014

References
  1. Russell-Silver syndrome. Genetics Home Reference. 2008; http://ghr.nlm.nih.gov/condition=russellsilversyndrome. Accessed 11/30/2011.