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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Schwannoma


Other Names for this Disease

  • Cellular schwannoma (histologic variant)
  • Melanotic schwannoma (histologic variant)
  • Neurilemoma
  • Neurinoma
  • Plexiform schwannoma (histologic variant)
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Inheritance

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Are schwannomas hereditary?

Schwannomas are not considered hereditary if an individual develops only one schwannoma, unless there is also a family history of schwannoma.  However, individuals who develop more than one schwannoma are thought to have a genetic predisposition to develop these tumors.[1][2]  Multiple schwannomas can be caused by one of two hereditary conditions, neurofibromatosis type 2 or schwannomatosis. Two articles studied individuals with schwannoma: one found that only 5% of affected individuals developed multiple schwannomas[1]; the other showed that 10% developed multiple schwannomas[2]. This suggests that 90-95% of individuals with schwannoma do not have a genetic condition and developed the schwannoma by chance.
Last updated: 7/22/2014

References
  1. Antinheimo J, Sankila R, Carpen O, Pukkala E, Sainio M, Jaaskelainen J.. Population-based analysis of sporadic and type 2 neurofibromatosis-associated meningiomas and schwannomas. Neurology. 2000; 54(1):71-76. http://www.ncbi.nlm.nih.gov/pubmed/10636128. Accessed 7/22/2014.
  2. Gonzalvo A, Fowler A, Cook RJ, Little NS, Wheeler H, McDonald KL, Biggs MT. Schwannomatosis, sporadic schwannomatosis, and familial schwannomatosis: a surgical series with long-term follow-up. Clinical article.. Journal of Neurosurgery. 2011; 113(3):752-765. http://www.ncbi.nlm.nih.gov/pubmed/20932094. Accessed 7/22/2014.


Other Names for this Disease
  • Cellular schwannoma (histologic variant)
  • Melanotic schwannoma (histologic variant)
  • Neurilemoma
  • Neurinoma
  • Plexiform schwannoma (histologic variant)
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.