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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Juvenile retinoschisis


Other Names for this Disease
  • Retinoschisis juvenile X chromosome-linked
  • Retinoschisis X-linked
  • X-linked juvenile retinoschisis
  • X-linked retinoschisis
  • XJR
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Your Question

Does juvenile retinoschisis cause blindness inevitably?  At approximately what age do they go blind?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

How does juvenile retinoschisis affect vision?

People with juvenile retinoschisis begin to experience vision loss during childhood, in some cases as early as 3 months of age. At first, affected males have vision of 20/60 to 20/120. Their vision declines with age, but generally stabilizes after age 20. Visual sharpness remains unchanged in most people until their forties or fifties, when a significant decline in visual acuity typically occurs.[1]
Last updated: 2/23/2010

Does juvenile retinoschisis always lead to blindness?

The effects on vision in juvenile retinoschisis are quite variable.  As such, it is difficult to predict how each affect individual's vision will change over time.  However, nearly all affected individuals over 70 are legally blind due to the typical progression of this disease.  Juvenile retinoschisis may cause other complications that threaten sight at any age, including detachment of the retina (which may occur in up to 22% of individuals with this condition) or bleeding (hemorrhage) into the vitreous gel of the eye (which may affect up to 40%).[2]
Last updated: 2/26/2013

References