Your browser does not support javascript:   Search for gard hereSearch for news-and-events here.


Genetic and Rare Diseases Information Center (GARD)

Print friendly version

Complex regional pain syndrome

Other Names for this Disease
  • CRPS
  • Reflex sympathetic dystrophy syndrome
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.


Newline Maker

What are the signs and symptoms of complex regional pain syndrome?

Complex regional pain syndrome most often affects one of the arms, legs, hands, or feet. Often the pain spreads to include the entire arm or leg.[1]  Typical features include dramatic changes in the color and temperature of the skin over the affected limb or body part, accompanied by intense burning pain, skin sensitivity, sweating, and swelling.  Other symptoms may include changes in nail or hair growth, thin and dry skin, stiff muscles and joints, loss of muscle, limited mobility in the affected limb, and muscle and tendon contractions.[2]
Last updated: 10/19/2011

  1. NINDS Complex regional pain syndrome information page. National Institute of Neurological Disorders and Stroke. April 2011; Accessed 10/19/2011.
  2. Complex regional pain syndrome. MedlinePlus. 2008; Accessed 5/20/2009.