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Genetic and Rare Diseases Information Center (GARD)

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Corticobasal degeneration

Other Names for this Disease
  • CBGD
  • Cortical-Basal Ganglionic degeneration
  • Cortico-Basal Ganglionic Degeneration (CBGD)
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Your Question

Is corticobasal degeneration hereditary? If so, is there anything that can be done to slow it down?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

What is corticobasal degeneration?

Corticobasal degeneration is characterized by the break down (degeneration) of parts of the brain, including the cerebral cortex and basal ganglia. The cerebral cortex is responsible for most of the brain's processing of information, and the basal ganglia are deep brain structures that help start and control movement. Signs and symptoms of corticobasal degeneration include poor coordination, loss of movement, rigidity, poor balance, unnatural posturing of the muscles, intellectual (cognitive) impairment, speech impairment, muscular jerks, and difficulty swallowing. These symptoms develop and worsen over time. Currently the cause of corticobasal degeneration is not known.[1]
Last updated: 5/4/2010

Is corticobasal degeneration hereditary?

Currently the cause of corticobasal degeneration is not known. There is no strong evidence to suggest that corticobasal degeneration is inherited.[2] You can read more this and more about the cause of corticobasal degeneration at the WEMOVE Web site at the following link.
Last updated: 5/4/2010

Is there anything that can be done to slow the progression of corticobasal degeneration?

No. Currently there is not a treatment available to slow the course of corticobasal degeneration. Treatment of corticobasal degeneration is supportive.[1] 

The following resource can be used to search for clinical trials enrolling people with corticobasal degeneration. Some of the trials may involve the investigation of new therapies.

The U.S. National Institutes of Health, through the National Library of Medicine, developed to provide patients, family members, and members of the public with current information on clinical research studies. Currently, a clinical trial is identified as enrolling individuals with corticobasal degeneration. To find this trial, click here. After you click on the study, review its "eligibility" criteria to determine its appropriateness. Use the study’s contact information to learn more. Check this site often for regular updates.

You can also contact the Patient Recruitment and Public Liaison (PRPL) Office at the National Institutes of Health (NIH) to speak with a specialist, who can help you determine if you are eligible for any clinical trials.

Patient Recruitment and Public Liaison Office
NIH Clinical Center
Bethesda, Maryland 20892-2655
Toll-free: 800-411-1222
Fax: 301-480-9793
Web site:
Last updated: 4/20/2011