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Genetic and Rare Diseases Information Center (GARD)

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Triple A syndrome

Other Names for this Disease
  • AAA
  • AAA syndrome
  • Achalasia Addisonianism Alacrimia syndrome
  • Achalasia alacrima syndrome
  • Addisonian achalasia syndrome
More Names
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Your Question

My 15 year old daughter was recently diagnosed with triple A syndrome. Is there anything that can be done about her abnormal sweating? We have tried various types of treatments and so far none have worked.

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

How might excessive sweating associated with triple A syndrome be treated?

Many of the features of triple A syndrome, including abnormally increased sweating (hyperhidrosis), are caused by dysfunction of the autonomic nervous system (dysautonomia), which controls involuntary body processes.[1] In most cases, the goal of treating secondary hyperhidrosis (caused by a primary underlying condition) is to treat the underlying condition; unfortunately, there is no cure for dysautonomia so only symptomatic treatment may be possible.[2]

Most of the treatments for hyperhidrosis discussed in the medical literature involve primary and/or focal hyperhidrosis, which is often idiopathic (of unknown cause). Treatment options for these have included medications, antiperspirants, iontophoresis, Botulinum toxin type A (Botox), endoscopic thoracic sympathectomy (ETS), and surgical intervention.[3] Several studies have mentioned that generalized hyperhidrosis may optionally be treated with systemic anticholinergic agents,[4] which are used to prevent the stimulation of sweat glands.[3] However, the associated adverse effects have somewhat limited their use.[4]

Antidepressant drugs such as amitriptyline and paroxetine, as well as antihypertensive drugs (blood pressure medications) such as beta blockers, calcium channel antagonists, alpha antagonists, and alpha-2 agonists have been described in single case reports as only slightly to moderately effective.[5]
Last updated: 6/14/2011