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Genetic and Rare Diseases Information Center (GARD)

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Juvenile primary lateral sclerosis

Other Names for this Disease
  • JPLS
  • PLS juvenile
  • Primary lateral sclerosis, juvenile
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What are the signs and symptoms of juvenile primary lateral sclerosis?

Juvenile primary lateral sclerosis is a rare disorder characterized by progressive weakness and stiffness of muscles in the arms, legs, and face. Symptoms of juvenile primary lateral sclerosis begin in early childhood and progress over a period of 15 to 20 years. Early symptoms include clumsiness, muscle spasms, weakness and stiffness in the legs, and difficulty with balance. As symptoms progress, they include weakness and stiffness in the arms and hands, slurred speech, drooling, difficulty swallowing, and an inability to walk.[1]
Last updated: 3/4/2011

  1. Juvenile primary lateral sclerosis. Genetics Home Reference (GHR). 2007; Accessed 3/4/2011.