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Genetic and Rare Diseases Information Center (GARD)

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Cronkhite-Canada disease

Other Names for this Disease
  • Polyposis skin pigmentation alopecia fingernail changes
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Cronkhite-Canada syndrome is a rare gastrointestinal disorder. It is characterized by widespread colon polyps, unhealthy looking (dystrophic) nails, hair loss (alopecia), darkening skin (such as on the hands, arms, neck and face), diarrhea, weight loss, and stomach pain. The cause of the condition is not known. Treatment aims to control symptoms and provide adequate nutrition.[1][2]
Last updated: 12/20/2010


  1. Kao KT, Patel JK, Pampati V. Gastroenterol Res Pract. Epub 2009 Aug 25; Accessed 12/20/2010.
  2. Serwin AB, Mysliwiec. Cronkhite-Canada syndrome. eMedicine. 2009; Accessed 12/20/2010.
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Basic Information

  • CHORUS (Collaborative Hypertext of Radiology) has a page on Cronkhite-Canada syndrome. Click on CHORUS to view the page.
  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.

In Depth Information

  • Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
  • The Online Mendelian Inheritance in Man (OMIM) is an catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Cronkhite-Canada disease. Click on the link to view a sample search on this topic.

Selected Full-Text Journal Articles