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Genetic and Rare Diseases Information Center (GARD)

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Normokalemic periodic paralysis

Other Names for this Disease
  • Normokalemic PP
  • NormoKPP
  • Periodic paralysis type 3
  • Potassium-sensitive normokalemic periodic paralysis
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How might normokalemic periodic paralysis be treated?

Although much progress has been made in understanding periodic paralysis, there is currently no consensus on treatment and effective treatment options are limited.[1] Furthermore, likely because many experts do not consider normokalemic periodic paralysis to be a distinct condition (it is thought to be a variant of hyperkalemic periodic paralysis), there is little information available in the medical literature regarding this specific variant of the rare condition.

The limited research that has been published has suggested that carbonic acid anhydrase inhibitors may reduce attack frequency and severity in periodic paralysis. However, there has not been sufficient information in terms of which of the carbonic acid anhydrase inhibitors (dichlorphenamide or acetazolamide) is more effective or has fewer side effects.[1]

Experts generally agree that affected individuals should avoid the triggers of attacks through lifestyle and dietary modification.[2] It has been reported that people with the hyperkalemic form can prevent attacks by eating frequent meals rich in carbohydrates and low in potassium and by avoiding fasting, strenuous activity, and exposure to cold.[3] Symptoms of individuals who are normokalemic during attacks may be improved by exercising.[2]
Last updated: 9/12/2012

  1. Sansone V, Meola G, Links TP, Panzeri M, Rose MR. Treatment for periodic paralysis. Cochrane Database Syst Rev. January 2008; 23(1):
  2. S. L. Venance et al. The primary periodic paralyses: diagnosis, pathogenesis and treatment. Brain. 2006; 129:8-17.
  3. Michael Rubin. Periodic paralysis. Merck Manuals. January 2008; Accessed 9/12/2012.