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Diseases

Genetic and Rare Diseases Information Center (GARD)

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3p deletion syndrome


Other Names for this Disease

  • 3p- syndrome
  • Chromosome 3, monosomy 3p25
  • Del(3p) syndrome
  • Deletion 3p25
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Inheritance

Newline Maker

Is 3p deletion syndrome inherited?

In most cases, 3p deletion syndrome is not inherited from a parent. It usually occurs for the first time in the affected person. However, in a few cases, the deletion is inherited from a parent. If a parent has the same deletion as the affected child, the chance for each child of that parent to have the deletion can be 50% (1 in 2). If neither parent has the deletion, it is very unlikely that they will have another child with 3p deletion syndrome.

In theory, it is possible for a parent to not have the deletion in their chromosomes on a blood test, but have the deletion in some of their egg or sperm cells only. This phenomenon is called germline mosaicism.  In these rare cases, it would be possible to have another child with the deletion. To our knowledge, this has not been reported with 3p deletion syndrome.[1]

People interested in learning more about genetic risks to themselves or family members should speak with a genetics professional.
Last updated: 7/8/2014

References
  1. 3p25 deletions. Unique. 2013; http://www.rarechromo.org/information/Chromosome%20%203/3p25%20deletions%20FTNW.pdf. Accessed 7/8/2014.


Other Names for this Disease
  • 3p- syndrome
  • Chromosome 3, monosomy 3p25
  • Del(3p) syndrome
  • Deletion 3p25
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.