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Genetic and Rare Diseases Information Center (GARD)

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Hereditary lymphedema type II


Other Names for this Disease

  • Lymphedema hereditary type 2
  • Lymphedema praecox
  • Lymphedema, hereditary, II
  • Lymphedema, late-onset
  • Meige disease
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Overview

What is hereditary lymphedema type II?

What are the signs and symptoms of hereditary lymphedema type II?

What causes hereditary lymphedema type II?

How is hereditary lymphedema type II inherited?

What is hereditary lymphedema type II?

Hereditary lymphedema type II is a primary lymphedema that results from abnormal transport of lymph fluid. Individuals with this condition usually develop swelling in the lower legs and feet during puberty. Some affected individuals develop a non-contagious skin infection called cellulitis, which can further damage the lymphatic vessels (the thin tubes that carry lymph fluid). While the cause of hereditary lymphedema type II is unknown, it is thought to be genetic because it tends to run in families. It appears to have an autosomal dominant pattern of inheritance.[1]
Last updated: 2/9/2012

What are the signs and symptoms of hereditary lymphedema type II?

Hereditary lymphedema type II is characterized by the abnormal transport of lymph fluid. This causes the lymph fluid to build up, causing swelling (lymphedema). Individuals with hereditary lymphedema type II usually develop swelling in the lower legs and feet during puberty. Some affected individuals develop a non-contagious skin infection called cellulitis, which can further damage the lymphatic vessels (the thin tubes that carry lymph fluid).[1]   
Last updated: 2/9/2012

What causes hereditary lymphedema type II?

The cause of hereditary lymphedema type II is unknown. The condition is thought to be genetic because it tends to run in families. Researchers have studied many genes associated with the lymphatic system; however, to date, no specific genetic change has been associated with this type of lymphedema.[1]
Last updated: 2/9/2012

How is hereditary lymphedema type II inherited?

Hereditary lymphedema type II appears to have an autosomal dominant pattern of inheritance, which means that one copy of an altered gene in each cell is sufficient to cause the disorder. People with hereditary lymphedema type II usually have at least one other affected family member, in most cases, a parent. When the condition occurs in only one person in a family, the condition is described as Meige-like lymphedema.[1]
Last updated: 2/9/2012

References
  1. Meige lymphedema. Genetics Home Reference (GHR). November 2010; http://ghr.nlm.nih.gov/condition/meige-lymphedema. Accessed 2/9/2012.


Other Names for this Disease
  • Lymphedema hereditary type 2
  • Lymphedema praecox
  • Lymphedema, hereditary, II
  • Lymphedema, late-onset
  • Meige disease
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.