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Genetic and Rare Diseases Information Center (GARD)

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Wells syndrome

Other Names for this Disease
  • Bullous cellulitis with eosinophilia
  • Eosinophilic cellulitis
  • Wells' syndrome
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Wells syndrome is a rare eosinophilic disorder characterized by itchy, burning, red, and inflamed areas on the skin often on the lower arm or leg. The lesions may be single or multiple. They are usually red at first (looking like cellulitis) then change to brown red, to blue gray, then greenish gray. The lesions are usually painful and are sometimes associated with a fever. They typically heal without scarring within weeks to months; however they often recur. The cause of Wells syndrome is unknown; but some researchers think that Wells syndrome is an autoimmune reaction.[1][2]
Last updated: 12/14/2011


  1. Wells syndrome . DermNet NZ. September 2011; Accessed 12/14/2011.
  2. Familial eosinophilic cellulitis. National Organization for Rare Disorders (NORD). 2009; Accessed 12/14/2011.
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Basic Information

  • DermNet NZ is an online resource about skin diseases developed by the New Zealand Dermatological Society Incorporated. DermNet NZ provides information about this condition.
  • MedlinePlus provides more information on eosinophilic disorders. MedlinePlus is a Web site designed by the National Library of Medicine to help you research your health questions.
  • The Merck Manual Online Medical Dictionary provides information on eosinophilic disorders. The Merck Manuals are a series of healthcare books for medical professionals and consumers.
  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.

In Depth Information

  • Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Wells syndrome. Click on the link to view a sample search on this topic.