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Keratosis palmoplantaris papulosa

Other Names for this Disease
  • Buschke fischer brauer syndrome
  • Keratoderma, palmoplantar punctate type 1
  • Keratodermia palmoplantaris papulosa, Buschke-Fischer-Brauer type
  • Type I punctate palmoplantar keratoderma
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What are the signs and symptoms of keratosis palmoplantaris papulosa?

Signs and symptoms of keratosis palmoplantaris papulosa tend to become evident between the ages of 10 to 30 years. Symptoms include multiple, tiny, hard rounded bumps of thickened skin on the palms of the hands and soles of the feet. The bumps may join to form calluses on pressure points. The legions may cause pain, making walking difficult and impairing hand/finger movement.[1][2][3] Symptoms tend to worsen with time and may be aggravated by manual work or injury.[1]

In some families, keratosis palmoplantaris papulosa appears to be associated with an increased risk for cancer.[1][2][3][4]
Last updated: 11/9/2012

  1. Oztas P et al.,. Punctate palmoplantar keratoderma (Brauer-Buschke-Fisher Syndrome). Am J Clin Dermatol. 2007;
  2. Erkek E et al.,. Type I Hereditary punctuate keratoderma associated with widespread lentigo simplex and successfully treated with low-dose oral acitretin. Arch Dermatology. 2006 Aug;
  3. Asadi AK. Type I hereditary punctuate keratoderma. Dermatology Online Journal. 2003;
  4. Keratoderma, palmoplantar, punctuate type I. Online Mendelian Inheritance in Man. 2009; Accessed 3/10/2010.