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Genetic and Rare Diseases Information Center (GARD)

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Tylosis with esophageal cancer

Other Names for this Disease
  • Howel-Evans syndrome
  • Keratosis palmaris et plantaris with esophageal cancer
  • Keratosis palmoplantaris with esophageal cancer
  • TOC
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What are the signs and symptoms of Tylosis with esophageal cancer?

The main features of Tylosis with esophageal cancer are palmoplantar keratoderma and esophageal cancer. The palmoplantar keratoderma usually begins around age 10, and the soles of the feet are usually more severely affected that the palms of the hands. Esophageal carcinoma usually develops in the lower two-thirds of the esophagus at an average age of 45 years.[1]
Last updated: 1/18/2013

  1. Sybert VP. Genetic Skin Disorders. New York: Oxford University Press; 1997;