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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Jones syndrome


Other Names for this Disease

  • Familial gingival fibromatosis associated with progressive deafness
  • GFD
  • Gingival fibromatosis with progressive deafness
  • Gingival fibromatosis with sensorineural hearing loss
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Overview

Jones syndrome is a very rare condition characterized by gingival fibromatosis (enlargement and overgrowth of the gums) and progressive, sensorineural hearing loss.[1] The onset of gingival fibromatosis usually occurs with the eruption of the permanent teeth. Excessive growth of the gums may cause displacement of teeth, over-retention of primary teeth, and increased spacing.[2] Jones syndrome is inherited in an autosomal dominant manner, but the underlying genetic cause is not yet known.[1] Only a few families with Jones syndrome have been reported.
Last updated: 10/7/2014

References

  1. Gingival fibromatosis - progressive deafness. Orphanet. May, 2007; http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Expert=2027&lng=EN. Accessed 10/6/2014.
  2. Aghili H, Goldani Moghadam M. Hereditary gingival fibromatosis: a review and a report of a rare case. Case Rep Dent. 2013; Accessed 10/7/2014.
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In Depth Information

  • Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Jones syndrome. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Familial gingival fibromatosis associated with progressive deafness
  • GFD
  • Gingival fibromatosis with progressive deafness
  • Gingival fibromatosis with sensorineural hearing loss
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.