Your browser does not support javascript:   Search for gard hereSearch for news-and-events here.

Diseases

Genetic and Rare Diseases Information Center (GARD)

Print friendly version

Internal carotid agenesis


Other Names for this Disease
  • Agenesis of the internal carotid artery
  • Internal carotid artery agenesis
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview


Internal carotid agenesis occurs when one of the blood vessels which supply blood to the brain does not develop (agenesis).  It is rare, occurring in less than 0.01% of people.[1]  Usually there is a pair of internal carotid arteries, one on the left side and one on the right side; agenesis occurs on the left side three times more frequently than on the right side.[2]  Individuals with this condition may not have any symptoms because there are several blood vessels transporting blood to the brain such that if one does not develop, the others can function in its place.  However, if symptoms occur, they may include headache, blurred vision, paralysis of some of the nerves in the head (palsy), epilepsy, or muscle weakness on one side of the body (hemiparesis).[2]  The main concern with internal carotid agenesis is the increased risk for enlargement of the other blood vessels (aneurysm), which can occur in up to 67% of people with this condition (compared to 2-4% of individuals without this condition).[3]
Last updated: 3/17/2011

References

  1. Afifi, AK, Goersky JC, Menezes A, Smoker WR, Bell WE, and Jacoby CG. Cerebral Hemiatrophy, Hypoplasia of Internal Carotid Artery, and Intracranial Aneurysm: A Rare Association Occuring in an Infant. Arch Neurol. 1987; 44:232-235. http://www.ncbi.nlm.nih.gov/pubmed?term=10428407. Accessed 3/14/2011.
  2. Florio F, Balzano S, Nardella M, Strizzi V, Cammisa M, Bozzini V, Catapano G, and D'Angelo V. Congenital Absence of the Internal Carotid Artery. Vardiovasc Intervent Radiol. 1999; 22:74-78. http://www.ncbi.nlm.nih.gov/pubmed?term=9929551. Accessed 3/14/2011.
  3. Lee JH, Oh CW, Lee SH, and Han DH. Aplasia of the internal carotid artery. Acta Neruochin. 2003; 145:117-125. http://www.ncbi.nlm.nih.gov/pubmed/12601459. Accessed 3/14/2011.
  4. Claros P, Bandos R, GIlea I, Claros Jr A, Capdevila A, Gardia Rodrigues J, Claros A. Major congenital anomalies of the internal carotid artery: agenesis, aplasia and hypoplasia. Int J Pediatr Otorhinolaryngol. 1999; 49:69-76. http://www.ncbi.nlm.nih.gov/pubmed?term=10428407. Accessed 3/14/2011.
Your Questions Answered
by the Genetic and Rare Diseases Information Center

1 question(s) from the public on Internal carotid agenesis have been answered. See questions and answers. You can also submit a new question.
On this page

In Depth Information

  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Internal carotid agenesis. Click on the link to view a sample search on this topic.