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Genetic and Rare Diseases Information Center (GARD)

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Hallermann-Streiff syndrome


Other Names for this Disease
  • Francois dyscephalic syndrome
  • Hallermann Streiff Francois syndrome
  • Hallermann Streiff syndrome
  • HSS
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Overview


Hallermann-Streiff syndrome is a rare, congenital condition characterized mainly by abnormalities of the skull and facial bones; characteristic facial features; sparse hair; eye abnormalities; dental defects; degenerative skin changes; and proportionate short stature.[1][2] Intellectual disability is present in some individuals.[2] Almost all reported cases of the condition appear to have occurred randomly for unknown reasons (sporadically) and are thought to have resulted from a new mutation in the affected individual.[3] Treatment is symptomatic and supportive.[4]
Last updated: 7/23/2012

References

  1. Graham JM. Hallermann Streiff Syndrome. National Organization for Rare Disorders (NORD). 2008; http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Hallermann%20Streiff%20Syndrome. Accessed 3/19/2010.
  2. Hallerman-Streiff Syndrome. Online Mendelian Inheritance in Man (OMIM). 2010; http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=234100. Accessed 3/19/2010.
  3. Hallermann Streiff Syndrome. NORD. April 11, 2012; http://www.rarediseases.org/rare-disease-information/rare-diseases/byID/498/viewAbstract. Accessed 7/23/2012.
  4. David LR, Finlon M, Genecov D, Argenta LC. J Craniofac Surg. 1999; http://www.ncbi.nlm.nih.gov/pubmed/10388418. Accessed 3/19/2010.
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Basic Information

  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.

In Depth Information

  • The Online Mendelian Inheritance in Man (OMIM) is an catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Hallermann-Streiff syndrome. Click on the link to view a sample search on this topic.