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Genetic and Rare Diseases Information Center (GARD)

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Your Question

Could you please send me information on hypoaldosteronism? My daughter has been diagnosed with this condition and I am trying to find out more about it.

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

What is hypoaldosteronism?

Hypoaldosteronism is a condition characterized by the shortage (deficiency) or impaired function of a hormone called aldosterone. Hypoaldosteronism may be described as hyporeninemic or hyperreninemic depending on renin levels. Hyporeninemic hypoaldosteronism occurs when there is decreased production of aldosterone due to decreased production of renin . Affected individuals typically have kidney (renal) disease due to various conditions, such as diabetes, interstitial nephritis, or multiple myeloma. Hyperreninemic hypoaldosteronism occurs when there is a problem with the production of aldosterone, but renin is produced normally by the kidneys. Common causes of this form of hypoaldosteronism are medications (ACE inhibitors), lead poisoning, severe illness, and aldosterone enzyme defects.[1]
Last updated: 5/4/2010

How might hypoaldosteronism be treated?

Treatment for hypoaldosteronism depends on the underlying condition. Affected individuals are often advised to follow a low-potassium diet with liberal sodium intake. People with hypoaldosteronism should typically avoid ACE inhibitors and potassium-sparing diuretics. Individuals with hypoaldosteronism and a deficiency of adrenal glucocorticoid hormones are usually given fludrocortisone. People with hyporeninemic hypoaldosteronism are frequently given furosemide to correct hyperkalemia.[1][2]
Last updated: 5/4/2010

  • Ferri FF. Ferri's Clinical Advisor 2010. Phildelphia: Mosby; 2009;
  • Ferri FF. Practical Guide to the Care of the Medical Patient, 7th ed. Philadelphia: Mosby; 2007;