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Menetrier disease

Other Names for this Disease
  • Gastroenteropathy, protein losing
  • Giant hypertrophic gastritis
  • Giant hypertrophic gastropathy
  • Giant hypertrophy of the gastric mucosa
  • Hypertrophic gastropathy
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Ménétrier disease is a condition characterized by inflammation and ulcers of the mucosa (inner lining) of the stomach and by overgrowth of the cells that make up the mucosa. [1] The condition is associated with the following signs: protein loss from the stomach, excessive mucus production, and hypochlorhydria (low levels of stomach acid) or achlorhydia (absent levels of stomach acid). [2]  Symptoms usually include vomiting, diarrhea, and weight loss. The disease may increase an individual's risk of developing stomach cancer. [1][3]
Last updated: 8/14/2008


  1. Dictionary of Cancer Terms. National Cancer Institute. Accessed 8/14/2008.
  2. Chapter 47 - Stomach. Townsend: Sabiston Textbook of Surgery, 18th ed.. Philadelphia: Saunders, An Imprint of Elsevier; 2007;
  3. Caroline DF, Kendzierski RM. Chapter 31 - The Stomach. Adam: Grainger & Allison's Diagnostic Radiology, 5th ed.. Churchill Livingstone; 2008;
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Basic Information

  • The National Cancer Institute provides the most current information on cancer for patients, health professionals, and the general public.  Click on the link to view information on this topic. 
  • The National Digestive Diseases Information Clearinghouse (NDDIC), part of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), offers information on this condition. Click on the link to view information on this topic.
  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.

In Depth Information

  • The Online Mendelian Inheritance in Man (OMIM) is an catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Menetrier disease. Click on the link to view a sample search on this topic.