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Genetic and Rare Diseases Information Center (GARD)

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Ehlers-Danlos syndrome, classic type

Other Names for this Disease
  • Classic Ehlers-Danlos syndrome
  • Ehlers-Danlos syndrome type 1 (formerly)
  • Ehlers-Danlos syndrome type 2 (formerly)
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Your Question

Is there a proanthocyanidin that is particularly helpful for Ehlers-Danlos syndrome, classic type? I want to support my body's ability to make stronger collagen.

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

What is Ehlers-Danlos syndrome, classic type?

Ehlers-Danlos syndrome (EDS), classic type, is an inherited connective tissue disorder characterized by skin hyperextensibility, abnormal wound healing, and joint hypermobility. The classic type is made up of two previously designated subtypes (EDS type I and EDS type II) which represent a continuum of clinical features. About 50% of people with EDS, classic type have mutations in COL5A1 or COL5A2, two genes which encode type V collagen. The condition is inherited in an autosomal dominant manner.[1]
Last updated: 6/15/2011

What causes Ehlers-Danlos syndrome, classic type?

Mutations in COL5A1, and COL5A2 cause some cases of Ehlers-Danlos syndrome, classic type. These genes provide instructions for making proteins that are used to assemble different types of collagen. Collagens are molecules that give structure and strength to connective tissues throughout the body. These mutations disrupt the structure, production, or processing of collagen, preventing these molecules from being assembled properly. These defects weaken connective tissues in the skin, bones, and other parts of the body, resulting in the characteristic features of this condition.[2]
Last updated: 6/15/2011

Is there a proanthocyanidin that is particularly helpful for Ehlers-Danlos syndrome, classic type?

While proanthocyanidins appear to strengthen connective tissue and stabilize collagen, there is no literature to support the use of these compounds in people with Ehlers-Danlos syndrome. 
Last updated: 6/15/2011