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Dysplasia epiphysealis hemimelica


Other Names for this Disease

  • Trevor disease
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Overview

Dysplasia epiphysealis hemimelica (DEH), or Trevor's disease, is a rare condition that most commonly affects the epiphysis (the end) of long bones in children.[1][2] Early diagnosis and treatment are necessary to prevent joint dysfunction and deformity and may be surgical or non-surgical depending on the location and the symptoms.[3][4] Due to the progressive nature of this disorder and the chance of worsening deformity, patients should be followed until skeletal maturity.[5] The cause of dysplasia epiphysealis hemimelica is not known.[2]
Last updated: 5/10/2011

References

  1. Wenger DR, Adamczk MJ. Evaluation, imaging, histology and operative treatment for dysplasia epiphysealis hemimelica (Trevor disease) of the acetabulum: a case report and review. Iowa Orthop J. 2005; http://www.ncbi.nlm.nih.gov/pubmed/16089075. Accessed 5/10/2011.
  2. Glick R, Khaldi L, Ptaszynski K, Steiner GC. Dysplasia epiphysealis hemimelica (Trevor disease): a rare developmental disorder of bone mimicking osteochondroma of long bones. Hum Pathol. 2007; http://www.ncbi.nlm.nih.gov/pubmed/17490719. Accessed 5/10/2011.
  3. Rosero VM, Kiss S, Terebessy T, Kollo K, Szoke G. Dysplasia epiphysealis hemimelica (Trevor's disease): 7 of our own cases and a review of the literature. Acta Orthop. 2007; http://www.ncbi.nlm.nih.gov/pubmed/18236195. Accessed 5/10/2011.
  4. Douira-Khomsi W, Louati H, Mormech Y, et al.. Dysplasia epiphysealis hemimelica: a report of four cases. Foot Ankle Surg. 2011; http://www.ncbi.nlm.nih.gov/pubmed/21276564. Accessed 5/10/2011.
  5. Smith EL, Raney EM, Matzkin EG, Fillman RR, Yandow SM. Trevor's disease: the clinical manifestations and treatment of dysplasia epiphysealis hemimelica. J Pediatr Orthop B. 2007; http://www.ncbi.nlm.nih.gov/pubmed/17527110. Accessed 5/10/2011.
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Basic Information

  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.

In Depth Information

  • Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
  • The Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Dysplasia epiphysealis hemimelica. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Trevor disease
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.