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Other Names for this Disease
- Congenital dysfibrinogenemia
- Dysfibrinogenemia, familial
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 Dysfibrinogenemia may increase a person's risk of venous thrombosis or rarely cause a mild bleeding tendency. PT, PTT, and Thrombin Time tests are used to screen for this condition, which is then confirmed with additional specialized blood tests. Patients with dysfibrinogenemia may experience poor wound healing. Hereditary transmission is autosomal dominant or codominant except in a few cases that appear to be transmitted recessively.Dysfibrinogenemia is a rare coagulation disorder caused by a mutation in the gene controlling the production of fibrinogen in the liver. It causes the liver to make an abnormal fibrinogen, one that resists degradation when converted to fibrin.
Last updated: 12/9/2009
- Fibrinogen. Lab Tests Online. 2009; http://www.labtestsonline.org/understanding/analytes/fibrinogen/test.html. Accessed 12/9/2009.
- Mosesson MW. Hereditary Abnormalities of Fibrinogen. In: Beutler E, Lichtman M, Coller BS, Kipps TJ, Geligsohn U. Williams Hematology, 6th ed.. NY: McGraw-Hill; 2001;
- Brick W, Burgess R, Faguet GB. Dysfibrinogenemia. eMedicine. 2009; http://emedicine.medscape.com/article/199723-overview. Accessed 12/9/2009.
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- The Online Mendelian Inheritance in Man (OMIM) database contains genetics resources that discuss Dysfibrinogenemia. Click on the link to go to OMIM and review these resources.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Dysfibrinogenemia. Click on the link to view a sample search on this topic.