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Yellow nail syndrome

Other Names for this Disease
  • Lymphedema with yellow nails
  • YNS
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Yellow nail syndrome is characterized by yellow nails that lack a cuticle, grow slowly, and are loose or detached (onycholysis). Yellow nail syndrome is often associated with diseases of the lung or lymphedema.[1]  Yellow nail syndrome often affects older adults, though it can occur at any age.[2][3]  While the exact cause of this condition is unknown, it has been shown to run in some families, which suggests that there may be a genetic component in some cases.[2]  Unfortunately, there is no cure for this condition, but there are therapies available to treat the related lung diseases and lymphedema.[3]
Last updated: 1/12/2012


  1. Yellow nail syndrome. MedlinePlus. 2011; Accessed 1/11/2012.
  2. Maldonado F. Yellow Nail Syndrome. National Organization for Rare Disorders (NORD). 2012; Accessed 1/11/2012.
  3. Vignes S. Yellow nail syndrome. Orphanet. 2007; Accessed 1/11/2012.
Your Questions Answered
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3 question(s) from the public on Yellow nail syndrome have been answered. See questions and answers. You can also submit a new question.

Basic Information

  • DermNet NZ is an online resource about skin diseases developed by the New Zealand Dermatological Society Incorporated. DermNet NZ provides information about this condition.
  • MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.

In Depth Information

  • The Online Mendelian Inheritance in Man (OMIM) is an catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Yellow nail syndrome. Click on the link to view a sample search on this topic.