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Genetic and Rare Diseases Information Center (GARD)

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Best vitelliform macular dystrophy

Other Names for this Disease
  • Best disease
  • Best macular dystrophy
  • Macular degeneration, polymorphic vitelline
  • Vitelliform macular dystrophy type 2
  • VMD2
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Your Question

My girlfriend has Best vitelliform macular dystrophy and I feel helpless because she tells me there is nothing anyone could do. Are there any clinical trials or research studies for this type of disease? Is there any treatment that can help? Also, can you go completely blind from this condition?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

Is there treatment for individuals with Best vitelliform macular dystrophy?

There is no specific treatment for Best vitelliform macular dystrophy at this time.[1][2]  Low vision aids provide benefit for those individuals with significant deterioration in visual acuity.[3] Laser photocoagulation, photodynamic therapy, and anti-VEGF (vascular endothelial growth factor) agents such as bevacizumab have shown limited success in treating some of the secondary manifestations of Best vitelliform macular dystrophy such as choroidal neovascularization (when abnormal blood vessels grow under the macula and retina).[3][1][2] 

Most current research is aimed at understanding the genetic cause of the disorder, which may aid in the development of treatment options.[4]
Last updated: 1/17/2013

Are there any clinical trials for Best vitelliform macular dystrophy?

The U.S. National Institutes of Health, through the National Library of Medicine, developed to provide patients, family members, and members of the public with current information on clinical research studies. To find these trials, click on the link above and use "Best vitelliform macular dystrophy" as your search term. After you click on a study, review its "eligibility" criteria to determine its appropriateness. Use the study’s contact information to learn more. Check this site often for regular updates.

You can also contact the Patient Recruitment and Public Liaison (PRPL) Office at the National Institutes of Health (NIH). We recommend calling the toll-free number listed below to speak with a specialist, who can help you determine if you are eligible for any clinical trials. If you are located outside the United States, and would like to be contacted via telephone, you will need to provide your telephone number in full, including area code and international dialing prefix.

Patient Recruitment and Public Liaison Office
NIH Clinical Center
Bethesda, Maryland 20892-2655
Toll-free: 800-411-1222
Fax: 301-480-9793
Web site:

Last updated: 1/17/2013

What research is currently being done on Best vitelliform macular dystrophy?

You can find relevant articles on Best vitelliform macular dystrophy through PubMed, a searchable database of biomedical journal articles. Although not all of the articles are available for free online, most articles listed in PubMed have a summary available. To obtain the full article, contact a medical/university library or your local library for interlibrary loan. You can also order articles online through the publisher’s Web site. Using "Best vitelliform macular dystrophy" as your search term should help you locate articles. Use the advanced search feature to narrow your search results. Click here to view a search.

The National Library of Medicine (NLM) Web site has a page for locating libraries in your area that can provide direct access to these journals (print or online). The Web page also describes how you can get these articles through interlibrary loan and Loansome Doc (an NLM document-ordering service). You can access this page at the following link You can also contact the NLM toll-free at 888-346-3656 to locate libraries in your area.

Last updated: 1/17/2013

Can individuals with Best vitelliform macular dystrophy become completely blind?

The severity of vision loss varies widely in individuals with Best vitelliform macular dystrophy. People with this condition often lose their central vision and their eyesight may become blurry or distorted.  However, peripheral (side) vision and the ability to see at night usually remain unaffected.[5][6]
Last updated: 10/11/2011