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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Baller-Gerold syndrome


Other Names for this Disease
  • BGS
  • Craniosynostosis with radial defects
  • Craniosynostosis-radial aplasia syndrome
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Symptoms


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What are the signs and symptoms of Baller-Gerold syndrome?

Many people with Baller-Gerold syndrome have prematurely fused skull bones along the coronal suture, the growth line that goes over the head from ear to ear. Other parts of the skull may be malformed as well. These changes result in an abnormally shaped head, a prominent forehead, and bulging eyes with shallow eye sockets (ocular proptosis). Other distinctive facial features can include widely spaced eyes (hypertelorism), a small mouth, and a saddle-shaped or underdeveloped nose.[1]

Bone abnormalities in the hands include missing fingers (oligodactyly) and malformed or absent thumbs. Partial or complete absence of bones in the forearm is also common. Together, these hand and arm abnormalities are called radial ray malformations.[1]

People with Baller-Gerold syndrome may have a variety of additional signs and symptoms including slow growth beginning in infancy, small stature, and malformed or missing kneecaps (patellae). A skin rash often appears on the arms and legs a few months after birth. This rash spreads over time, causing patchy changes in skin coloring, areas of skin tissue degeneration, and small clusters of enlarged blood vessels just under the skin. These chronic skin problems are collectively known as poikiloderma.[1]

Last updated: 5/25/2011

References
  1. Baller-Gerold syndrome. Genetics Home Reference (GHR). 2008; http://ghr.nlm.nih.gov/condition/baller-gerold-syndrome. Accessed 5/26/2011.