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Genetic and Rare Diseases Information Center (GARD)

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Craniofrontonasal dysplasia

Other Names for this Disease
  • CFND
  • CFNS
  • Craniofrontonasal dysostosis
  • Craniofrontonasal syndrome
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Your Question

Could I have gender issues because of craniofrontonasal dysplasia?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

Can craniofrontonasal dysplasia cause issues related to gender?

Based on an extensive review of the available resources, craniofrontonasal dysplasia has not been noted to cause gender issues.  However, this condition may occasionally affect parts of the body associated with gender.  For example, asymmetry of the breasts or abnormalities of the uterus or Mullerian ducts has been noted in a few women with craniofrontonasal dysplasia, and hypospadias or an unusually shaped scrotum has been found in a few men.[1]  Because craniofrontonasal dysplasia is a rare condition, there is limited information about the potential psychological implications of the physical features associated with this condition.
Last updated: 9/29/2011

  • Wieacker P, Wieland I. Clinical and genetic aspects of craniofrontonasal syndrome: towards resolving a genetic paradox. Molecular Genetics and Metabolism. 2005; 86:110-116. Accessed 9/28/2011.