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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Congenitally corrected transposition of the great arteries


Other Names for this Disease

  • Congenitally corrected transposition of the great vessels
  • Transposition of the great arteries, congenitally corrected
  • Transposition of the great vessels, congenitally corrected
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Overview

What is congenitally corrected transposition of the great arteries?

What causes congenitally corrected transposition of the great arteries?

What is congenitally corrected transposition of the great arteries?

Congenitally corrected transposition of the great arteries is a rare heart defect that occurs when the ventricles and attached valves are switched. As a result, the aorta and the pulmonary artery are connected to the wrong lower heart chambers.[1][2] Click here to visit MayoClinic.com and view an image of this heart defect. While the oxygen-poor blood still flows to the lungs, and oxygen-rich blood still flows out to nourish the body, other heart problems (such as septal defects, pulmonary stenosis, tricuspid regurgitation, and heart block) are often associated with this defect and require treatment.[2]
Last updated: 1/6/2012

What causes congenitally corrected transposition of the great arteries?

Currently the cause of congenitally corrected transposition of the great arteries is not known. Limited data suggests that air pollutants and hair dye may act as environmental risk factors for this rare defect. Also, having a family history of this heart defect is a risk factor. It has been estimated that the recurrence risk in siblings is around 3% to 5%.[3]
Last updated: 1/6/2012

References
  1. Congenitally Corrected Transposition of the Great Arteries. MayoClinic.com. http://www.mayoclinic.org/diseases-conditions/transposition-of-the-great-arteries/basics/definition/con-20043232. Accessed 1/6/2011.
  2. Congenitally Corrected Transposition of the Great Arteries. MayoClinic.com. http://www.mayoclinic.org/transposition-of-the-great-arteries/. Accessed 1/6/2011.
  3. Wallis et al.,. Congenitally corrected transposition. Orphanet Journal of Rare Diseases. 2011;6:22; http://www.ojrd.com/content/pdf/1750-1172-6-22.pdf. Accessed 1/6/2012.


Other Names for this Disease
  • Congenitally corrected transposition of the great vessels
  • Transposition of the great arteries, congenitally corrected
  • Transposition of the great vessels, congenitally corrected
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.