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Genetic and Rare Diseases Information Center (GARD)

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Juvenile amyotrophic lateral sclerosis

Other Names for this Disease
  • Amyotrophic lateral sclerosis, juvenile
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What causes juvenile amyotrophic lateral sclerosis?

Juvenile amyotrophic lateral sclerosis (ALS) is often genetic and may be caused by mutations in the ALS2 or SETX genes. In some cases the underlying gene abnormality cannot be determined. Juvenile ALS may be inherited in an autosomal dominant (as in ALS type 4) or autosomal recessive (as in ALS type 2) fashion.[1][2]
Last updated: 7/8/2013

  1. Amyotrophic Lateral Sclerosis. Genetics Home Reference Web site. August 2007; Accessed 2/7/2008.
  2. Orban P, Devon RS, Hayden MR, Leavitt BR. Juvenile Amyotrophic Lateral Sclerosis. Handbook of Clinical Neurology. . 2007;82(3):301-312; Accessed 7/8/2013.