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Febrile infection-related epilepsy syndrome

Other Names for this Disease
  • Acute encephalitis with refractory repetitive partial seizures
  • Acute non-herpetic encephalitis with severe refractory status epilepticus
  • DESC syndrome
  • Devastating epileptic encephalopathy in school-aged children
More Names
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Febrile infection-related epilepsy syndrome (FIRES) is a severe brain disorder that develops in children after a fever. This condition results in sudden seizures and leads to declines in memory and intellectual ability. FIRES can also cause psychiatric disorders or problems with motor skills. The cause of FIRES is unknown, but may be related to infection, genetic susceptibility, an autoimmune disorder, or a problem with metabolism. Treatment involves antiepileptic medications to manage seizures, but they do not usually work well.[1]
Last updated: 3/19/2013


  1. Van Baalen A. Febrile infection-related epilepsy syndrome. Orphanet. July 2012; Accessed 3/19/2013.
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  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Febrile infection-related epilepsy syndrome. Click on the link to view a sample search on this topic.