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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Linear and whorled nevoid hypermelanosis


Other Names for this Disease
  • Linear and whorled hypermelanosis
  • LWNH
  • Nevoid hypermelanosis, linear and whorled
  • Reticulate hyperpigmentation of Iijima
  • Zebra-like hyperpigmentation
More Names
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Symptoms


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What are the signs and symptoms of linear and whorled nevoid hypermelanosis?

Signs and symptoms of linear and whorled nevoid hypermelanosis include swirling streaks of hyperpigmented (darkened) skin.  The hyperpigmentation may or may not be apparent at birth, but tends to present by infancy or early childhood. Unlike other rare hyperpigmented skin conditions, the hyperpigmentation occurs without inflammation, blisters, or warty lesions. The hyperpigmentation follows the lines of Blashko and may involve part or much of the body (eyes, palms of the hands, soles of the feet, and mucous membranes are usually not affected). The skin symptoms may progress for one to two years before stabilizing. Children with linear and whorled nevoid hypermelanosis often have otherwise normal physical and neurologic development, however individual cases occurring along with neurologic, heart, growth, and skeletal abnormalities have been described.[1]
Last updated: 3/18/2013

References
  1. Mehta V, Vasanth V, Balachandran C, Mathew M. Linear and whorled nevoid hypermelanosis. Int J Dermatol. 2011 Apr;50(4):491-2; http://www.ncbi.nlm.nih.gov/pubmed/21413967. Accessed 3/18/2013.