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Genetic and Rare Diseases Information Center (GARD)

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Linear and whorled nevoid hypermelanosis

Other Names for this Disease
  • Linear and whorled hypermelanosis
  • LWNH
  • Nevoid hypermelanosis, linear and whorled
  • Reticulate hyperpigmentation of Iijima
  • Zebra-like hyperpigmentation
More Names
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How might linear and whorled nevoid hypermelanosis be treated?

There is very limited information regarding the treatment of linear and whorled nevoid hypermelanosis. Chemical peels and 2% hydroquinone for treatment of skin hyperpigmentation has been described.[1] Due to the possible association with chromosome abnormalities and other symptoms, each person with linear and whorled nevoid hypermelanosis should undergo a thorough evaluation for developmental delays, growth retardation, and skeletal anomalies, such as facial and body asymmetry, and congenital heart defects.[1]
Last updated: 3/18/2013

  1. Mehta V, Vasanth V, Balachandran C, Mathew M. Linear and whorled nevoid hypermelanosis. Int J Dermatol. 2011 Apr;50(4):491-2; Accessed 3/18/2013.

Clinical Trials & Research for this Disease

  • Orphanet lists clinical trials, research studies, and patient registries enrolling people with this condition. Click on Orphanet to view the list.